Sɛ́ ade titiriw a wɔde fa nneɛma mu wɔ nnɛyi nnuruyɛ mu no, .enteric a ɛwɔ nipadua no mu-a wɔakata socapsules a wɔde hyɛ nipadua muwɔde di dwuma kɛse wɔ nnuruyɛ mu esiane mfaso horow a ɛwɔ so nti, te sɛ beae pɔtee a wɔayi no adi, nnuru a ɛbɔ ho ban fi yafunu mu acid sɛe ho, ne nnuru a ɛmma yafunu mu ntini no nhyɛ abufuw. Nanso, bere a wɔreyɛ na wɔkora so ankasa no, bere a enteric capsules no mu paapae no taa yɛ su ho sɛnkyerɛnne a ɛho hia a ɛyɛ den sɛ wobedi so. Sɛ wɔkyɛ sɛ ɛpaapae anaasɛ woyi no adi ntɛm a, ɛka aduru no bioavailability ne ayaresa mu mmɔdenbɔ tẽẽ. Enti, dɛn ankasa ne nneɛma a ɛka enteric-coated capsules no mpaapaemu?
Nea edi kan koraa no, nneɛma a ɛwɔ akorade no mu ne ne su ne nneɛma atitiriw a ɛkyerɛ sɛnea mpaapaemu no yɛ adwuma.Enteric capsules a wɔde hyɛ nipadua no mumpɛn pii no wɔde di dwumagelatin a wɔde yɛ nneɛmasɛ ade a wɔde gyina so, a wɔde enteric polymers te sɛ acrylic resins, cellulose acetate phthalate (CAP), anaa shellac ka ho. Saa nneɛma a ɛwɔ akyi berɛmo yi mu a wɔpete no gyina pH bo a ɛwɔ dwensɔtwaa no mu nneɛma a atwa yɛn ho ahyia no so. Sɛ aduru a wɔde kata dwensɔtwaa mu no nsusuwii nsusuwii nyɛ nea ɛfata-sɛ nhwɛso no, sɛ nneɛma a ɛma sini-yɛ no dodow dɔɔso dodo-ebetumi ama akorade no ntumi nsɛe anaasɛ asɛe ntɛmntɛm wɔ dwensɔtwaa mu nsu no mu, na ɛnam so ama mpaapaemu no aboro bere a wɔahyɛ no so. Bio nso, gelatin no ankasa nhwiren ahoɔden, viscosity, ne sɛnea cross-linking reactions no nso nya nsuo a ɛtwetwe ne nea ɛpete wɔ capsule shell no mu tẽẽ.
Nea ɛto so abien no, .akwan a wɔfa so yɛ nneɛmane tebea horow a wɔde sie no di dwuma titiriw. Wɔ capsule molding nhyehyɛe no mu no, drying temperature ne bere a wɔbɛhwɛ so no ho hia titiriw. Sɛ ɛyow dodo a, ebetumi ama nsu a ɛwɔ akorade no mu no ayɛ ketewaa dodo, na ama ayɛ mmerɛw dodo na ayɛ den, na ɛka sɛnea ɛyɛ nsu na nipadua mu nsu kɔ mu no; nea ɛne no bɔ abira no, nsu a ɛdɔɔso dodo betumi ama abon no ayɛ mmerɛw anaasɛ asɛe. Nea ɛsɛ sɛ yɛhyɛ no nsow kɛse mpo ne sɛ nsu a ɛyɛ nwini, ɔhyew, ne hann a ɛwɔ...nneɛma a wɔkora sobetumi akanyan "cross-linking" adeyɛ a ɛwɔ gelatin mu. Saa cross-linking effect yi yɛ nsuo-insolveble network structure wɔ shell no ani, na ɛma capsule no ntumi nnye nsuo na ɛpaapae sɛdeɛ ɛteɛ wɔ onipa nipadua mu akyi, adeyɛ a wɔtaa frɛ no "insolubility".
Awiei koraa no, wontumi mmu ani ngu nneɛma a wɔde hyɛ mu no su so. Ɛwom sɛ mpaapaemu no de n’ani si akorade no so titiriw de, nanso nkɛntɛnso a emu nsɛm no nya no yɛ nokwasɛm a wɔde wɔn ani asi so. Sɛ aduru a wɔahyɛ no ma no wɔ acid anaa alkalinity a emu yɛ den, anaasɛ aldehydes pii wom a, ebetumi ama nnuru ne ade a ɛwɔ akorade no mu ayɛ adwuma ntɛmntɛm, na ama akisikuru no atumi agyina pintinn. Eyi betumi ama yafunu no mu apaapae ntɛm anaasɛ asiw nsu a ɛba dwensɔtwaa no mu sɛnea ɛsɛ no kwan.
Sɛ yɛbɛbɔ no mua a, nneɛma a ɛka enteric empty capsules a ɛpaapae no wɔ afã horow pii, a nea ɛka ho ne nnuru a ɛwɔ nneɛma a wɔde yɛ nneɛma mu, sɛnea wɔhwɛ nneɛma a wɔyɛ so, ne sɛnea nneɛma a wɔkora so no gyina pintinn. Ɛsɛ sɛ nnwumakuw a wɔyɛ nnuru hwɛ nneɛma a wɔde yɛ nnuru no yiyedi so denneennen, wɔma akwan a wɔfa so ma ɛyow no yɛ papa, na wɔhwɛ hu sɛ baabi a wɔkora nneɛma a ɛyɛ nwini na ɛyɛ kusuu. Ɛdenam saa nneɛma yi a yɛbɛhwɛ so yiye nkutoo so na yebetumi ahwɛ ahu sɛ enteric-coated capsules no mu paapae na wogyae no pɛpɛɛpɛ na ɛyɛ adwuma yiye wɔ nipadua no mu, na ɛnam so ama aduru no ayɛ adwuma yiye wɔ ayaresabea.
