Nnuru a wɔde gu nipadua mu a hwee nni mu no yɛ nneɛma a ɛho hia a wɔde fa nnuru ne aduannuru, na wɔn nipadua mu nneɛma yɛ nea ɛyɛ mmerɛw kɛse. Eyinom mu no, nsu a ɛwɔ mu no yɛ ade titiriw a ɛkyerɛ sɛnea nneɛma te. Nsu a ɛboro so betumi ama capsules ayɛ mmerɛw, asɛe, anaasɛ mpo abata ho, bere a nsu a ɛnnɔɔso ma ɛyɛ mmerɛw na ɛyɛ mmerɛw sɛ ɛbɛpaapae bere a wɔde rekɔ na wɔde asie no. Enti, nyansahu ne pɛpɛɛpɛ a wobehu nsu a ɛwɔ capsules a hwee nni mu mu no yɛ ade a ɛho hia a wɔde hwɛ sɛnea nnuru no te yiye wɔ nnwumakuw a wɔyɛ nnuru mu.
Mprempren, nsu a ɛwɔ nsukorade a hwee nni mu mu a wobehu no gyina nnyinasosɛm a ɛne sɛ nipadua mu duru sesa ne nnuru a wɔde yɛ nhwehwɛmu so titiriw. Wɔ sɔhwɛ a wɔahyɛ da ayɛ a nnuruyɛfo kyerɛ mu no, ɔkwan a wɔtaa de di dwuma ne Loss on Drying (LOD) kwan no. Eyi hwehwɛ sɛ wɔma nhwɛsode no yɛ hyew ma nsu no yɛ nwini, na afei wogyina nsonsonoe a ɛwɔ mu duru mu ansa na ayow ne bere a wɔayow akyi no so bu nsu a ɛwɔ mu no ho akontaa. Wɔ gelatin capsules ho no, ɔhyew a wɔhwɛ so denneennen bere a wɔresɔ ahwɛ no ho hia kɛse esiane sɛnea ɛyɛ hyew nti; wɔtaa de fononoo a ɛma ɔhyew a ɛyɛ hyew daa di dwuma. Nea ɛbɛyɛ na wɔasiw gelatin no a ɛyɛ hyew ano no, ɛtɔ mmere bi a wɔde vacuum drying di dwuma, na ɛma nsu no tumi yɛ hyew wɔ ɔhyew a ɛba fam mu wɔ nhyɛso a wɔatew so mu. Ɛwom sɛ saa kwan a wɔagye din yi ma wonya nea ɛyɛ pɛpɛɛpɛ de, nanso ɛtaa gye bere-na ɛpere sɛ ɛbɛma wɔadi ahwehwɛde a ɛfa mmuae a wɔde ma ntɛmntɛm wɔ nnɛyi nneɛma a wɔyɛ mu no ho dwuma.
Nea ɛbɛyɛ na sɔhwɛ ahorow no atu mpɔn no, wɔde mfiri a wɔde hwehwɛ nsu mu ntɛmntɛm adi dwuma kɛse wɔ nnwuma no mu wɔ nnansa yi mfe mu. Saa nnwinnade yi taa de halogen ɔhyew anaa infrared radiation mfiridwuma di dwuma de ma nhwɛsode ahorow yɛ hyew tẽẽ, na ɛma bere a wɔde ma ɛyow no yɛ tiaa kɛse. Wɔn adwumayɛ nnyinasosɛm nso gyina mu duru a wɔtew so, nanso wɔde nneɛma a wɔde kari nneɛma a ɛyɛ pɛpɛɛpɛ a ɛkorɔn ne ɔhyew sohwɛ nhyehyɛe a nyansa wom bom de hwɛ nsakrae a ɛba wɔ nhwɛsode mu duru mu no ara kwa na wɔabu nsu a ɛwɔ mu wɔ bere ankasa mu. Sɛ wɔde toto atetesɛm fononoo akwan ho a, saa kwan yi yi hia a ehia sɛ wɔde nsa kari mpɛn pii na wɔma ɛyɛ nwini no fi hɔ, na ɛma nea efi mu ba wɔ simma kakraa bi mu, na ɛma ɛyɛ nea eye ma in-process control ne nhwehwɛmu ntɛmntɛm bere a wɔreyɛ no.
Wɔ akwan a egyina thermogravimetric nnyinasosɛm ahorow so akyi no, Karl Fischer titration yɛ ɔkwan foforo a ɛho hia a wɔfa so hu. Saa nnuru kwan yi gyina nnuru dodow a iodine ne nsu yɛ adwuma so na ɛkyerɛ nsu a ɛwɔ mu. Wɔ capsules a hwee nni mu a ɛyɛ hyew-te nka kɛse anaasɛ ɛwɔ nneɛma a ɛyɛ hyew, Karl Fischer titration ma detection pɛpɛɛpɛ a ɛkorɔn yiye na ebetumi mpo akyerɛ nsu kakraa bi. Nanso, esiane sɛ ɛhwehwɛ kɛse wɔ reagents ne nneɛma a atwa yɛn ho ahyia ho, ne sɛnea ɛyɛ adwuma a ɛyɛ den kakra nti, wɔtaa de di dwuma ma arbitration analysis anaa nhwehwɛmu mfuw mmom sen sɛ wɔde bɛyɛ ade titiriw a wɔpaw ma da biara da nneɛma a wɔyɛ daa.
Bio nso, ɛnam nkɔsoɔ a wɔde nyansa yɛ wɔ nnuruyɛ mu nti, wɔafi aseɛ de Near-Infrared Spectroscopy (NIR) nso redi dwuma de ahu nsuo a ɛwɔ capsule mu wɔ intanɛt so. Saa sɔhwɛ kwan a ɛnyɛ-sɛe ade yi hyɛ nsuo a ɛwɔ mu ho nkɔm denam nhwehwɛmu a wɔyɛ wɔ nhwɛsoɔ a ɛwɔ hann a ɛbɛn-infrared a wɔde akontabuo nhwɛsoɔ ho no su a ɛtwetwe nsuo mu. Ne mfasoɔ kɛseɛ ne sɛ wɔrensɛe nhwɛsoɔ, reagents biara nni hɔ, ne ahoɔhare a wɔde hu ntɛmntɛm paa, a ɛma wotumi yɛ bere ankasa-, kɔ so hwɛ na egyina hɔ ma akwankyerɛ a ɛho hia ma daakye adwumayɛbea a nyansa wom.
Sɛ yɛbɛbɔ no mua a, akwan horow wɔ hɔ a wɔfa so hu nsu a ɛwɔ mucapsules a hwee nni mu. Wɔ dwumadie a mfasoɔ wɔ so mu no, ɛsɛ sɛ nnwumakuo paw ɔkwan a ɛfata a wɔfa so hwehwɛ nneɛma a egyina wɔn dwumadie pɔtee a wɔhwehwɛ, nhwehwɛmu a wɔhwehwɛ no pɛpɛɛpɛ, ne sɛdeɛ wɔyɛ no ntɛmntɛm so. Sɛ́ ebia wɔde atetesɛm fononoo kwan anaa nnɛyi mfiri a wɔde hwehwɛ nneɛma mu ntɛmntɛm bedi dwuma no, awiei koraa no, nea wɔde hwɛ hu sɛ nsɛm a wɔde hu nneɛma no yɛ pɛpɛɛpɛ na egyina pintinn no atirimpɔw ne sɛ wɔbɛma aduru a wɔde hyɛ nipadua mu a hwee nni mu no ayɛ papa, na wɔnam saayɛ so ahwɛ ahu sɛ nnuru no yɛ nea ahobammɔ wom na ɛyɛ adwuma yiye. Sɛ biribi wɔ hɔ a wɔhwehwɛ wɔ capsules a hwee nni mu ho a, Yɛma wo akwaaba sɛ wo ne KornnacCaps nni nkitaho.
