Sɛ́ ade a ɛho hia a wɔde fa nnuru, akwahosan ho nneɛma, ne nnuru a wɔde yɛ nnuru no, gelatin a wɔde hyɛ nipadua mu no mu nsu a ɛyɛ mmerɛw no nya nnuru no dodow a woyi fi mu, sɛnea wotumi twetwe nneɛma yiye, ne ayaresa a wɔde di dwuma wɔ ɔkwan a etwa to so no so nkɛntɛnso tẽẽ. Gelatin capsule a ɛpaapae no nyɛ nipadua mu nsakrae a ɛyɛ mmerɛw na mmom adeyɛ a ɛyɛ den a nneɛma pii nya so nkɛntɛnso, a nea ɛka ho ne nneɛma a wɔde yɛ adwuma no su, nneɛma a atwa yɛn ho ahyia tebea, ne nneɛma a wɔde hyɛ mu ma no su ahorow, a ɛda nneɛma a ɛda nsow adi.
pH-bere a wɔde siesie wɔn ho ne bere a wɔde paapae .
Gelatin a ɛyɛ gelatin no mu a ɛpaapae no kyerɛ sɛ ɛwɔ pH a ɛho hia kɛse. Wɔ yafunu no mu acidic tebea mu (pH 1-3) no, gelatin capsule shell no tumi twe nsu ntɛmntɛm, ɛho wosow, ɛyɛ mmerɛw, na awiei koraa no ɛpaapae, na mpɛn pii no, ɛyɛ adwuma no wie wɔ simma 5 kosi 30 mu de gyae emu nsɛm no. Saa su yi ma ɛyɛ nea eye sen biara a wɔpaw ma nnuru a wɔahyɛ da ayɛ sɛ wɔde bɛma wɔ yafunu mu. Sɛnea Chinafo nnuruyɛ kyerɛ no, ɛnsɛ sɛ bere a gelatin a wɔde hyɛ yafunu mu nsu mu no paapae no boro simma 30, a ɛyɛ ade titiriw a ɛkyerɛ sɛnea wɔhwɛ nneɛma so yiye. Nanso, ne nsu a ɛgu no yɛ brɛoo kakra wɔ baabi a ɛbɛn-neutral environment a ɛwɔ dwensɔtwaa no mu, a ɛma nsusuwii nnyinaso ma enteric-coated capsules nya nkɔso.
Ɔhyew ne ɔhyew ho nkate .
Gelatin yɛ nsu-Tone a ɛtumi nwura mu, na ne kwan a wɔfa so yiyi mu no yɛ nea ɛyɛ mmerɛw kɛse wɔ ɔhyew ne ɔhyew ho. Wɔ dan mu hyew mu no, gelatin abon no mu a ɛpaapae no yɛ brɛoo kakra, nanso sɛnea nsu no mu hyew kɔ soro kodu bɛyɛ digrii 37 (ɔyɛ nipadua no hyew no). Saa ara nso na nneɛma a atwa yɛn ho ahyia a ɛyɛ nwini no ka nsu a ɛwɔ capsules no mu no, na ɛno nso nya wɔn suban a wɔde gu mu no so nkɛntɛnso. Nsu a ɛyɛ nwini a ɛba fam dodo no betumi ama capsules no ayɛ mmerɛw na ayɛ mmerɛw sɛ ɛbɛpaapae bere a ɛregu no, bere a nsu a ɛyɛ hyew kɛse no betumi ama ayɛ mmerɛw ntɛm, abata ho, anaasɛ mpo abɔ mu-a ɛka bom, na ɛde ɔhaw ahorow a ɛyɛ den aba. Enti, ɛsɛ sɛ wɔhwɛ sɛnea wɔyɛ na wɔkora so wɔ aduru a hwee nni mu no mu katee wɔ tebea a ɛyɛ nwini na ɛyɛ kusuu mu (a mpɛn pii no ɛhwehwɛ sɛ ɔhyew a ɛyɛ digrii 10-25 ne ɔhyew a ɛyɛ 35%-65%).
Mmeamudua-a ɛde adeyɛ ne dissolution obstruction bata ho .
Wɔ storage anaasɛ contact ne binom nnuru ne excipients, gelatin capsules betumi ayɛ cross-linking reaction. Cross-Linking kyerɛ covalent nkitahodi a ɛyɛ den a ɛba gelatin molecule chains ntam, a ɛyɛ nsu-film a wontumi nnyina ano, a wɔtaa frɛ no pellicle anaa membrane. Saa sini yi siw nsu a ɛkɔ mu no kwan, na ɛma ɛkyɛ a ɛkyɛ anaasɛ mpo antumi ansɛe wɔ sɔhwɛ ahorow a wɔde hwɛ sɛnea nneɛma mu nsɛe no mu. Nneɛma titiriw a ɛkanyan mmeamudua-nkitahodi no bi ne: nneyɛe a ɛda amino acid ahorow a ɛwɔ gelatin mu, te sɛ lysine, ne aldehyde-Nnuru anaa nneɛma a wɔde boa; gelatin ankasa oxidation a wɔhyɛ ho nkuran wɔ ɔhyew ne ɔhyew a ɛkɔ soro ase; ne trace aldehydes a efi nneɛma a wɔde kyekyere nneɛma mu no tu kɔ baabi foforo. Sɛnea ɛbɛyɛ na wɔadi saa asɛm yi ho dwuma no, pharmacopeias ma kwan ma wɔde enzymes (te sɛ pepsin anaa pancreatin) ka dissolution medium no ho de yɛ IN{9}}vivo environment no ho mfonini, hwɛ hu sɛ ɛne in{10}}vitro dissolution results no hyia ne{11}}VIVO bioavailability ntam.
Nsonsonoe a ɛda mu wɔ-vivo ne mu-Vitro dissolution .
Ɛfata sɛ yɛhyɛ no nsow sɛ dissolution suban a gelatin capsules wɔ-vivo no taa ye sen nea ɛwɔ mu wɔ{1}}vitro sɔhwɛ ahorow mu. Eyi te saa efisɛ onipa yafunu mu ntini no kura aduan mu enzymes pii ne peristaltic movement, a ebetumi abubu cross-nhyehyɛe ahorow no yiye na ama capsule a ɛpaapae ne nnuru a woyi fi mu no anya nkɔso. Enti, sɛ mpo capsules bi kyerɛ sɛ ɛkyɛ wɔ mu{5}}vitro dissolution tests a, wɔn IN-Vivo bioavailability no, ebia ɛrennya nkɛntɛnso kɛse. Saa nsonsonoeɛ yi hwehwɛ sɛ atemmuo a ɛkɔ akyiri, a wɔde ka-vitro-wɔ-vivo correlation (IVIVC) mu no, ɛsɛ sɛ wɔyɛ wɔ nnuru a wɔyɛ ne ne su ho nhwehwɛmu mu.
Awie
gelatin capsules no su a ɛyɛ adwuma no yɛ ade titiriw wɔ wɔn dwumadi sɛ nnuru a wɔde di dwuma no mu. Efi pH-dependent disintegration ne nneɛma a atwa yɛn ho ahyia ho nkate so kosi nsɛnnennen a cross-linking ne nsonsonoe a ɛda in-vivo ne-vitro dissolution ntam no so no, afã biara nya formulation no su ne ne mmɔdenbɔ so nkɛntɛnso kɛse. Ɛnyɛ sɛ ntease a emu dɔ ne nyansahu mu mmara a ɛfa saa su ahorow yi ho no boa ma wɔyɛ capsule ahosiesie ho nhyehyɛe na wɔyɛ no yiye nko, na mmom ɛma ayarefo nya nnuru a ahobammɔ wom, etu mpɔn, na wotumi de ho to so, na ɛma wonya nkɔso bere nyinaa wɔ nnuruyɛ mu. Sɛ nsɛmmisa bi wɔ hɔ a ɛfa capsules a hwee nni mu ho a, yɛma wo akwaaba sɛ wo ne no bedi nkitaho .KornnacCaps ..
